Since Schumpeter first introduced innovation theory from the perspective of economics, the discussion on innovation has been continuously debated. Due to the increasingly obvious spatial trends of Humanities and Social Science and the increasingly mature spatial econometric analysis methods based on GIS, spatial research on innovation has become a key focus of many scholars, and includes the following topics: (1) Spatial distribution of innovation activities. The research scale ranges from county, city, provincial to the national level and the research methods are focused on
Moran’s I Index,
Location Gini Coefficient,
Lorenz Curve,
Variation Coefficient and other statistical methods. All the results revealed that innovation activities were highly concentrated and spatially imbalanced, revealing a scale-free property in the spatial distribution of innovation activities (
Lim, 2003;
Zhang et al., 2007;
Liu, 2010;
Wang et al., 2014;
Jiang, 2014). (2) Spatial spillover effects of regional innovation. It was discovered that there was a significant spatial correlation in terms of innovation among regions (
Moreno et al., 2005;
Su, 2006;
Zhang, 2013;
Guastella et al., 2015). Unlike the scale-free dependency of spatial distribution of innovation activities, there was a certain degree of spatial limitations in knowledge spillovers (
Lei Liang, 2015). (3) Influencing mechanism of the spatial distribution difference of innovation activities. Research in this area mainly established a regression model taking the innovation outputs or innovation efficiency as the dependent variable to reveal the factors influencing the spatial differences of innovation, which included innovation policy, foreign direct investment (FDI), enterprise scale, the industrial clusters and innovation environment, etc. (
Geroski, 1990;
Yu et al., 2007;
Fan et al., 2013;
Li et al., 2013;
Felsenstein, 2015). (4) Spatial evaluation of innovation strength and efficiency. Studies on the evaluation of regional innovation strength are mainly carried out by constructing a comprehensive evaluation and analysis model based on a series of evaluation index systems to explore the spatial differentiation between cities, regions or provinces (
Tao, 2013;
Fang et al., 2014;
Makkonen et al., 2014). Research on regional innovation efficiency was usually conducted from the input-output view to compare the efficiency of innovation activities at different spatial scales (
Wang et al., 2011;
Chen et al., 2012;
Fan et al., 2013;
Cheng et al., 2014). (5) Collaborative research on innovation and regional development. The driving effect of innovation on economic development has caught a large number of scholars’ attention since the 1990s. On the basis of a comprehensive evaluation of regional innovation strength and economic development level, a series of relational models were used to study the response and matching degree in space between regional innovation and its socioeconomic development (
Wang, 1999;
Cheng et al., 2011;
Niu et al., 2012). (6) Research on innovation links and innovation networks. The research scales concerning this topic were relatively macro, mainly including a country or a city on the global scale and a provincial or a prefecture-level city on the national scale. The research methods and perspectives were mainly on three aspects. The first was to study the spatial location and structure of the global R&D network by taking the global layout of research institutes of the Multi-National Corporation as an example from the perspective of enterprise spatial organization (
Zhu et al., 2005;
Zhang, 2015). The second was to measure the regional innovation contact intensity and pattern according to the innovation space gravity model based on the evaluation of regional innovation strength (
Lyu et al., 2015). The third was to study the structure and spatial complexity of the regional innovation network based on the social network analysis model from the perspective of regional innovation cooperation (
Lyu et al., 2014;
Li et al., 2015; Li
et al., 2015;
Berger et al., 2015).