This paper reviews the research on land use change and its corresponding ecological responses. Patterns of land use changes in spatio-temporal level are produced by the interaction of biophysical and socio-economic processes. Nowadays, the studies derived from different socioeconomic conditions and scales show that at short-term scale, human activities, rather than natural forces, have become a major force in shaping the environment, while biophysical factors control the trends and processes of land use change under the macro environmental background. Providing a scientific understanding of the process of land use change, the impacts of different land use decisions, and the ways that decisions are affected by a changing environment and increasing ecological variability are the priority areas for research: (1) explanation of scale dependency of drivers of land use change; (2) quantification of driving factors of land use change; (3) incorporation of biophysical feedbacks in land use change models; and (4) underlying processes and mechanisms of ecological impacts of land use change.