Based on the drought/flood grades of 90 meterological stations over eastern China and summer average sea-level pressure (SLP) during 1850-2008 and BPCCA statistical methods, the coupling relationship between the drought/flood grades and the East Asian summer SLP is analyzed. The East Asian summer monsoon index which is closely related with interdecadal variation of drought/flood distribution over eastern China is defined by using the key areas of SLP. The impact of the interdecadal variation of the East Asian summer monsoon on the distribution of drought/flood over eastern China in the last 159 years is researched. The results show that there are four typical drought and flood spatial distribution patterns in eastern China, i.e. the distribution of drought/flood in southern China is contrary to the other regions, the distribution of drought/flood along the Huanghe River-Huaihe River Valley is contrary to the Yangtze River Valley and regions south of it, the distribution of drought/flood along the Yangtze River Valley and Huaihe River Valley is contrary to the other regions, the distribution of drought/flood in eastern China is contrary to the western. The main distribution pattern of SLP in summer is that the strength of SLP is opposite in Asian continent and West Pacific. It has close relationship between the interdecadal variation of drought/flood distribution patterns over eastern China and the interdecadal variation of the East Asian summer monsoon which was defined in this paper, but the correlation is not stable and it has a significant difference in changes of interdecadal phase. When the East Asian summer monsoon was stronger (weaker), regions north of the Yangtze River Valley was more susceptible to drought (flood), the Yangtze River Valley and regions south of it were more susceptible to flood (drought) before the 1920s; when the East Asian summer monsoon was stronger (weaker), the regions north of the Yangtze River Valley was prone to flood (drought), the Yangtze River Valley and regions south of it were prone to drought (flood) after the 1920s. It is indicated that by using the data of the longer period could get much richer results than by using the data of the last 50-60 years. The differences in the interdecadal phase between the East Asian summer monsoon and the drought/flood distributions in eastern China may be associated with the nonlinear feedback, which is the East Asian summer monsoon for the extrinsic forcing of solar activity.