Due to the difficult logistics in the extreme high elevation regions over the Himala-yas and Tibetan Plateau, the observational meteorological data are very few. In 2003, an automatic weather station was deployed at the northeastern saddle of Mt. Nyainqentanglha (NQ) (30°24′44.3″ N, 90°34′13.1″ E, 5850 m a.s.l.), the southern Tibetan Plateau. In 2005, another station was operated at the East Rongbuk Glacier Col (28°01′0.95″ N, 86°57′48.4″ E, 6523 m a.s.l.) of Mt. Qomolangma. Observational data from the two sites have been com-pared with the reanalysis data from the National Centers for Environmental Predic-tion/National Center for Atmospheric Research (NCEP/NCAR), reliability of NCEP/NCAR reanalysis data has been investigated in the Himalayas/Tibetan Plateau region. The reanaly-sis data can capture much of the synoptic-scale variability in temperature and pressure, al-though the reanalysis values are systematically lower than the observation. Furthermore, most of the variability magnitude is, to some degree, underestimated. In addition, the weather event extracted from the NCEP/NCAR reanalyzed pressure and temperature prominently appears one day ahead of the observational data on Mt. Qomolangma, while on Mt. NQ it occurs basically in the same day.