The lower Yellow River still faces the threat of flood due to the unusual precipita-tion caused by global environmental change, river channel sedimentation, hidden danger in the dike and unfavorable river regime of “hanging river”. According to the characteristics of the dike-break flood of the Yellow River, this paper has simulated, in six different scenarios, the dike-break flood routing by inputting the terrain data, typical historical flood data and land use data of study area to two-dimensional unsteady flow model. The results show that: firstly, the routing process of flood will occupy other rivers on the way and return to the rivers after reaching the lower reaches; secondly, in the same river reach, flood inundating area of north band is bigger than that at corresponding location of south bank under the same historical flood; thirdly, it is different in the degree of flood inundation in different regions due to different geographical locations in flood plain; fourthly, the area of mainstream where flood is deep and flow velocity is quick is relatively smaller, but the area of non-mainstream, where flood is shallow and flow velocity is slow, is relatively big; and finally, the possible influenced area of the dike-break flood is 141,948 km².